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This paper introduces the concept of digital twins into the field of laboratory management, taking the twin-screw extrusion experimental device as an example, developed a digital twin management system for experimental devices. Starting from the informatization transformation of traditional equipment, the development process of the digital twin management system is introduced from the aspects of on-site data network transmission, laboratory network redundancy configuration, data management, and application management system development. The advantages of the digital twin management system are elaborated from the aspects of experimental safety, operation and maintenance costs, and experimental efficiency. The content covered in this article has certain guiding significance for the application of digital twin technology in laboratory management in colleges and universities and the informatization upgrade of equipment in small and medium-sized enterprises.